Abstract This research work describes the synthesis and biological properties of some novel isolated or fused heterocyclic ring systems with pyrazole, for example; enaminones containing pyrazolone ring photochromic functional unit, 4-[(4-chlorophenylamino) methylene]-3-methyl-1-phenyl-1H-pyrazol-5 (4H)-one (3) and some analogous derivatives 4, 9, and 10, also as pyrazolo [3, 4-b] pyridine, pyrazolo [3, 4-b] quinoline, pyrazolo [3′, 4 ...