edaravone

Modify Date: 2024-01-02 14:06:52

edaravone structure	Common Name	edaravone
	CAS Number	89-25-8	Molecular Weight	174.199
	Density	1.2±0.1 g/cm3	Boiling Point	333.0±11.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₀N₂O	Melting Point	126-128 °C(lit.)
	MSDS	Chinese USA	Flash Point	155.2±19.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of edaravone

Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

Name	edaravone
Synonym	More Synonyms

Description	Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Research Areas >> Neurological Disease
In Vitro	Edaravone performs both preventative and therapeutic effects against toxicity of glutamate. Pretreatment of edaravone reduces the toxicity of glutamate towards SGNs. Edaravone reduces apoptosis and necrosis caused by glutamate. Pretreatment of edaravone (500 μM) reverses these changes to approximately normal levels. The protective effect of edaravone on SGNs against glutamate-induced apoptosis is associated with PI3K/Akt pathway and Bcl-2 protein family[4].
In Vivo	Edaravone exerts neuroprotective effects by inhibiting endothelial injury and by ameliorating neuronal damage in brain ischemia. Edaravone provides the desirable features of NOS: it increases eNOS (beneficial NOS for rescuing ischemic stroke) and decreases nNOS and iNOS (detrimental NOS). Post-reperfusion brain edema and hemorrhagic events induced by thrombolytic therapy may be reduced by edaravone pretreatment[1]. Edaravone significantly decreases infarct volume, with the average infarct volume in the edaravone-treated rats (227.6 mm3) being significantly lower than that in the control rats (264.0 mm3). Edaravone treatment also decreases the postischemic hemorrhage volumes (53.4 mm3 in edaravone-treated rats vs 176.4 mm3 in controls). In addition, the ratio of hemorrhage volume to infarct volume is lower in the edaravone-treated rats (23.5%) than in the untreated rats (63.2%)[2]. In edaravone (20 mg/kg)-treated rats, astrocyte activity (glial fibrillary acidic protein) and apoptotic cells (caspase-3) are decreased on the corpus callosum, germinal matrix, and cerebral cortex[3].
Cell Assay	Cell viability is quantified by MTT assay and trypan blue staining. MTT (5 mg/mL, 20 μL) is added to each well and incubated for 4 h at 37°C after the drug treatments. The medium is removed and the cell pellet is dissolved in DMSO. Then, the optical density (OD) values are measured at 570 nm using an ELISA reader.
References	[1]. Yoshida, H., et al. Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev, 2006. 12(1): p. 9-20. [2]. Okamura, K., et al. Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia. Neurol Res, 2013. [3]. Garcia CA, et al. Edaravone reduces astrogliosis and apoptosis in young rats with kaolin-induced hydrocephalus. Childs Nerv Syst. 2016 Dec 17. [Epub ahead of print] [4]. Bai X, et al. Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plast. 2016;2016:4034218. Epub 2016 Nov 10.

Density	1.2±0.1 g/cm3
Boiling Point	333.0±11.0 °C at 760 mmHg
Melting Point	126-128 °C(lit.)
Molecular Formula	C₁₀H₁₀N₂O
Molecular Weight	174.199
Flash Point	155.2±19.3 °C
Exact Mass	174.079315
PSA	32.67000
LogP	0.44
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.606
Storage condition	Store at RT
Water Solubility	3 g/L (20 ºC)

edaravone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ9625000

CHEMICAL NAME :: 2-Pyrazolin-5-one, 3-methyl-1-phenyl-

CAS REGISTRY NUMBER :: 89-25-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H10-N2-O

MOLECULAR WEIGHT :: 174.22

WISWESSER LINE NOTATION :: T5NMV DHJ BR& E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2012 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Specific locus test

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 300 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 17,196,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83422 No. of Facilities: 11 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 114 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83422 No. of Facilities: 62 (estimated) No. of Industries: 5 No. of Occupations: 5 No. of Employees: 580 (estimated) No. of Female Employees: 137 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	UQ9625000
HS Code	2933199090

Precursor 8
CAS#:141-97-9 Ethyl acetoacetate CAS#:105-45-3 Methyl acetoacetate CAS#:100-63-0 Phenylhydrazine CAS#:59-88-1 Phenylhydrazine...
CAS#:27991-08-8 N-acetoacetylph... CAS#:6287-35-0 Ethyl 3-anilino... CAS#:626-34-6 Ethyl (2Z)-3-am... CAS#:70526-06-6 Ethyl (2Z)-3-(1...
DownStream 9
CAS#:4551-69-3 2-Pyrazolin-5-o... CAS#:60-80-0 Antipyrine CAS#:27349-35-5 5-methoxy-3-met... CAS#:1456-89-9 2-Phenyl-4-[[4-...
CAS#:143699-06-3 4-[(4-chlorophe... CAS#:51626-33-6 5-Chloro-3-Meth... CAS#:4702-90-3 Solvent Yellow 93 CAS#:41949-07-9 2-Diethylaminot...
CAS#:6972-27-6 1,3-Dimethyl-6-...

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage.

Leuk. Lymphoma 56(3) , 739-47, (2015)

The tumor suppressor p53 is often mutated in human cancers. Restoring its antitumor activity has been shown to be a promising therapeutic approach for cancer treatment. Here we analyzed the activity a...

The free radical scavenger, edaravone, ameliorates delayed neuropsychological sequelae after acute carbon monoxide poisoning in rabbits.

Undersea Hyperb. Med. 40(3) , 223-9, (2013)

The mechanism underlying delayed neuropsychological sequelae (DNS) after acute carbon monoxide (CO) poisoning is unclear. There are no effective treatments for DNS. As part of a new generation of anti...

Protective effect of edaravone against Alzheimer's disease-relevant insults in neuroblastoma N2a cells.

Neurosci. Lett. 531(2) , 160-5, (2012)

Oxidative stress has been demonstrated to be involved in the pathogenesis of Alzheimer's disease (AD). Thus, antioxidant therapy may represent a promising avenue for the treatment of AD. Edaravone (3-...

1-PHENYL-3-METHYL-5-PYRAZALONE

3-methyl-1-phenyl-1H-pyrazol-5(4H)-one

2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one

5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one

1-PHENYL-3-METHYL-5-PYRAZOLONE

1-PHENYL-3-METHYL-5-PYRAZOLE

3-METHYL-1-PHENYL-2-PYRAZOLIN-5ONE

MFCD00003138

1-PHENYL-3-METHYL-5- PYRAZOLONE

3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE FOR SYNTHESIS

3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ON

3-Methyl-1-phenyl-2-pyrazolin-5-one

3-Methyl-1-phenyl-5-pyrazolone

c.i. developer 1

3-Methyl-1-phenyl-2-pyrazoline-5-one

3-METHYL-1-PHENYL-2-PYRAZOLINE-5-ONE / EDARAVONE

1-PHENYL-3-METHYL-5-OXO-2-PYRAZOLINE

1-PHENYL-3-METHYL-2-PYRAZOLIN-5-ONE

Edaravone (MCI-186)

5-METHYL-2-PHENYL-1,2-DIHYDROPYRAZOL-3-ONE EDARAVONE

3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE (EDARAVONE)

1-pheny-3-methyl-5-pyrazolone (PMP)

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

EINECS 201-891-0

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: edaravone
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: edaravone
Price: ￥78.0/100g ￥268.0/500g
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Edaravone (MCI-186)
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Edaravone (MCI-186)
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Edaravone API
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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edaravone

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