Regioselective One??Pot Synthesis of Isocoumarins and Phthalides from 2??Iodobenzoic Acids and Alkynes by Temperature Control

…, FM Irudayanathan, JH Moon, S Lee

Index: Kumar, Manian Rajesh; Irudayanathan, Francis Mariaraj; Moon, Joong Ho; Lee, Sunwoo Advanced Synthesis and Catalysis, 2013 , vol. 355, # 16 p. 3221 - 3230

Full Text: HTML

Citation Number: 13

Abstract

Abstract: Copper-catalyzed coupling reaction of 2-iodobenzoic acids and alkynes such as terminal acetylenes, alkynyl carboxylic acids, and trimethylsilylacetylene selectively afforded isocoumarins and phthal-ACHTUNGTRENNUNGides in the presence of cesium carbonate (Cs2CO3) and dimethyl sulfoxide (DMSO). Among the regioselective products, only the 6- endo-dig product, isocoumarin, was formed at 1008C, and the 5-exo-dig product, ...