Tetrahedron letters

Selective displacement of aryl fluorides with hydroquinone: synthesis of 4-phenoxyphenols

BF Marcune, MC Hillier, JF Marcoux, GR Humphrey

Index: Marcune, Benjamin F.; Hillier, Michael C.; Marcoux, Jean-Francois; Humphrey, Guy R. Tetrahedron Letters, 2005 , vol. 46, # 45 p. 7823 - 7826

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Citation Number: 9

Abstract

The selective displacement of a variety of aryl fluorides with hydroquinone has been achieved to give substituted 4-phenoxyphenols. In some cases the addition of 18-crown-6 resulted in a significant rate enhancement, and the reactions could be carried out at lower temperature. One of these derivatives,(X= Cl) was converted to 2-propyl-4-(4- chlorophenoxy) phenol, a precursor to the PPARγ receptor agonist.