Russian journal of organic chemistry

α-Chlorobenzyl Isocyanates in a New Synthesis of 3, 4-Dihydropyrimidin-2 (1H)-ones

MV Vovk, VA Sukach

Index: Vovk; Sukach Russian Journal of Organic Chemistry, 2005 , vol. 41, # 8 p. 1240 - 1241

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Citation Number: 6

Abstract

5-Functionally substituted 3, 4-dihydropyrimidin-2 (1H)-ones constitute a unique heterocyclic system possessing versatile pharmacological properties [1–3]. The threecomponent cyclocondensation of 1, 3-dicarbonyl compounds with aldehydes and urea discovered by Biginelli [4] in 1893 is a traditional procedure for preparation of these compounds that is successfully used up till now. The other synthetic methods described [5–7] as a rule are ...