Tetrahedron: Asymmetry

CAL-B-catalyzed resolution of some pharmacologically interesting β–substituted isopropylamines

J González-Sabı́n, V Gotor, F Rebolledo

Index: Gonzalez-Sabin, Javier; Gotor, Vicente; Rebolledo, Francisca Tetrahedron Asymmetry, 2002 , vol. 13, # 12 p. 1315 - 1320

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Citation Number: 59

Abstract

Some pharmacologically active amines such as amphetamine, the isomeric o-, m-and p- methoxyamphetamines, 4-phenylbutan-2-amine and mexiletine, as well as their corresponding acetamides, have been prepared in high yields and with very high enantiomeric excesses. The method consists of the Candida antarctica lipase B (CAL-B)- mediated enantioselective acetylation of racemic amines using ethyl acetate as solvent ...