Synlett

3-arylpropanoate esters through the palladium-catalyzed reaction of aryl halides with acrolein diethyl acetal

G Battistuzzi, S Cacchi, G Fabrizi, R Bernini

Index: Battistuzzi, Gianfranco; Cacchi, Sandro; Fabrizi, Giancarlo; Bernini, Roberta Synlett, 2003 , # 8 p. 1133 - 1136

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Citation Number: 14

Abstract

Abstract The reaction of aryl halides with acrolein diethyl acetal in the presence of Pd (OAc) 2, n-Bu 3 N, and n-Bu 4 NCl in DMF at 90 C affords ethyl 3-arylpropanoates. A variety of functional groups are tolerated in the aryl halides, including ether, aldehyde, ketone, ester, nitrile, and nitro groups. ortho-Substituents do not hamper the reaction. 3-Arylpropanoate esters were isolated in good to excellent yields with many neutral, electron-rich and ...