Major metabolites of zolpidem: expeditious synthesis and mass spectra

F Klupsch, R Houssin, L Humbert, M Imbenotte…

Index: Klupsch, Frederique; Houssin, Raymond; Humbert, Luc; Imbenotte, Michel; Henichart, Jean-Pierre; Lhermitte, Michel Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 9 p. 1318 - 1321

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Citation Number: 12

Abstract

An expeditious route to the two major metabolites of Zolpidem—and readily applicable to the synthesis of the drug—was established via a cyclization reaction between a 2-aminopyridine and a suitable α-bromoacetophenone. The structures of the target compounds were confirmed from a 2D 1 H–15 N NMR correlation. Their mass spectra contribute to a reliable toxicological identification of the drug in the case of drug-facilitated crimes.