A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

…, GJ Price, S Schiffers, PR Raithby, PK Plucinski…

Index: White, James R.; Price, Gareth J.; Schiffers, Stefanie; Raithby, Paul R.; Plucinski, Pawel K.; Frost, Christopher G. Tetrahedron Letters, 2010 , vol. 51, # 30 p. 3913 - 3917

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Citation Number: 17

Abstract

The stable benzylazido-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide–alkyne cycloaddition and Suzuki coupling reactions.