e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis and radical scavenging activity of 3, 3-dialkyl-3, 4-dihydro-isoquinoline 2-oxides

…, AA Carr, TR Nieduzak, G Adams, DF Ohlweiler…

Index: Bernotas, Ronald C.; Thomas, Craig E.; Carr, Albert A.; Nieduzak, Thaddeus R.; Adams, Ginette; Ohlweiler, David F.; Hay, David A. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 10 p. 1105 - 1110

Full Text: HTML

Citation Number: 21

Abstract

The syntheses and antioxidant activities of several cyclic nitrones related to phenyl t-butyl nitrone (PBN) are described. These nitrones may act as radical scavengers and have potential uses in the treatment of stroke and septic shock.

1-Bromo-3-fluorobenzene Structure

1-Bromo-3-fluor...

3-Chloro-2-methyl-1-propene Structure

3-Chloro-2-meth...

~%

3-(3-FLUOROPHENYL)-2-METHYL-1-PROPENE Structure

3-(3-FLUOROPHEN...

2-Methyl-1-phenyl-2-propanol Structure

2-Methyl-1-phen...

~%

3,4-dihydro-3,3-dimethylIsoquinoline Structure

3,4-dihydro-3,3...

2-Methyl-1-phenyl-2-propanol Structure

2-Methyl-1-phen...

Sodium cyanide Structure

~71%

α,α-Dimethylphenethylformamide Structure

α,α-Dimethylphe...

m-Bromoanisole Structure

3-Chloro-2-methyl-1-propene Structure

3-Chloro-2-meth...

~%

3-(3-METHOXYPHENYL)-2-METHYL-1-PROPENE Structure

3-(3-METHOXYPHE...

4-Bromochlorobenzene Structure

4-Bromochlorobenzene

~%

N-[1-(4-chlorophenyl)-2-methyl-propan-2-yl]formamide Structure

N-[1-(4-chlorop...

1-chloro-4-(2-methylallyl)benzene Structure

1-chloro-4-(2-m...

Sodium cyanide Structure

~%

N-[1-(4-chlorophenyl)-2-methyl-propan-2-yl]formamide Structure

N-[1-(4-chlorop...

1-Bromo-4-fluorobenzene Structure

1-Bromo-4-fluor...

~%

N-[2-(4-FLUOROPHENYL)-1,1-DIMETHYLETHYL]FORMAMIDE Structure

N-[2-(4-FLUOROP...

3-(4-FLUOROPHENYL)-2-METHYL-1-PROPENE Structure

3-(4-FLUOROPHEN...

Sodium cyanide Structure

~%

N-[2-(4-FLUOROPHENYL)-1,1-DIMETHYLETHYL]FORMAMIDE Structure

N-[2-(4-FLUOROP...

1-benzylcyclopentanol Structure

1-benzylcyclope...

Sodium cyanide Structure

~%

N-(1-benzylcyclopentyl)formamide Structure

N-(1-benzylcycl...

3,4-dihydro-3,3-dimethylIsoquinoline Structure

3,4-dihydro-3,3...

~50%

3,3-dimethyl-2-oxido-4H-isoquinolin-2-ium Structure

3,3-dimethyl-2-...

4-Bromochlorobenzene Structure

4-Bromochlorobenzene

3-Chloro-2-methyl-1-propene Structure

3-Chloro-2-meth...

~%

1-chloro-4-(2-methylallyl)benzene Structure

1-chloro-4-(2-m...

1-Bromo-3,5-dichlorobenzene Structure

1-Bromo-3,5-dic...

3-Chloro-2-methyl-1-propene Structure

3-Chloro-2-meth...

~%

3-(3,5-DICHLOROPHENYL)-2-METHYL-1-PROPENE Structure

3-(3,5-DICHLORO...