3-Chloro-2-methyl-1-propene

Modify Date: 2026-07-02 12:31:24

3-Chloro-2-methyl-1-propene structure	Common Name	3-Chloro-2-methyl-1-propene
	CAS Number	563-47-3	Molecular Weight	90.551
	Density	0.9±0.1 g/cm3	Boiling Point	72.4±9.0 °C at 760 mmHg
	Molecular Formula	C₄H₇Cl	Melting Point	-80 °C
	MSDS	Chinese USA	Flash Point	-10.0±0.0 °C
	Symbol	GHS02, GHS05, GHS07, GHS09	Signal Word	Danger

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	3-Chloro-2-methylpropene
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	0.9±0.1 g/cm3
Boiling Point	72.4±9.0 °C at 760 mmHg
Melting Point	-80 °C
Molecular Formula	C₄H₇Cl
Molecular Weight	90.551
Flash Point	-10.0±0.0 °C
Exact Mass	90.023628
LogP	2.20
Vapour density	3.12 (vs air)
Vapour Pressure	129.6±0.1 mmHg at 25°C
Index of Refraction	1.410
InChIKey	OHXAOPZTJOUYKM-UHFFFAOYSA-N
SMILES	C=C(C)CCl
Water Solubility	0.5 g/L (20 ºC)

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

3-Chloro-2-methyl-1-propene MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UC8050000

CHEMICAL NAME :: Propene, 3-chloro-2-methyl-

CAS REGISTRY NUMBER :: 563-47-3

BEILSTEIN REFERENCE NO. :: 0878160

LAST UPDATED :: 199801

DATA ITEMS CITED :: 30

MOLECULAR FORMULA :: C4-H7-Cl

MOLECULAR WEIGHT :: 90.56

WISWESSER LINE NOTATION :: G1Y1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 22000 ppm/10M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 848 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - hypermotility, diarrhea Blood - hemorrhage

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 34 gm/m3/30M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3160 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - other changes Blood - changes in spleen

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 gm/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19500 mg/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 gm/m3/1H/5W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10500 mg/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 81250 mg/kg/13W-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 77250 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - adrenal cortex tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 38625 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 51500 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 51500 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 77250 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Reproductive - Tumorigenic effects - testicular tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 16 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 13,133,1989 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,325,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,325,1995 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,325,1995 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83971 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1683 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS02, GHS05, GHS07, GHS09
Signal Word	Danger
Hazard Statements	H225-H302 + H332-H314-H317-H411
Precautionary Statements	P210-P273-P280-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	F:Flammable;C:Corrosive;N:Dangerousfortheenvironment;
Risk Phrases	R11;R20/22;R34;R43;R51/53
Safety Phrases	S9-S16-S29-S36/37/39-S45-S61-S26
RIDADR	UN 2554 3/PG 2
WGK Germany	2
RTECS	UC8050000
Packaging Group	II
Hazard Class	3
HS Code	2903299090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 8
CAS#:32670-93-2 phosphoric acid... CAS#:115-11-7 Isobutylene CAS#:628-56-8 Dimethallyl ether CAS#:78538-54-2 tris(2-methylpr...
CAS#:64-19-7 acetic acid CAS#:3100-04-7 1-Methylcyclopropene CAS#:7782-50-5 Chlorine CAS#:594-37-6 Propane,1,2-dic...
DownStream 10
CAS#:10500-86-4 1,2-bis(2-methy... CAS#:10523-77-0 1-(Chloromethyl... CAS#:111719-00-7 2-[2-[2-(2-meth... CAS#:10474-14-3 1,2-Dibromo-3-c...
CAS#:109930-20-3 2-methyl-3-prop... CAS#:40463-03-4 1-methoxy-3-(3-... CAS#:3290-53-7 2-Methyl-3-phen... CAS#:300-57-2 Allylbenzene
CAS#:42288-08-4 3-methyl-3-(4-m... CAS#:4911-54-0 Ethyl 4-methyl-...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2903299090
Summary	2903299090 other unsaturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

NTP Toxicology and Carcinogenesis Studies of 3-Chloro-2-methylpropene (Technical grade containing 5% dimethylvinyl chloride) (CAS No. 563-47-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

Natl. Toxicol. Program Tech. Rep. Ser. 300 , 1-196, (1986)

Toxicology and carcinogenesis studies of technical-grade 3-chloro-2-methylpropene (containing 5% dimethylvinyl chloride), a widely used insecticide and a chemical intermediate, were performed on F344/...

3-Chloro-2-methylpropene.

IARC Monogr. Eval. Carcinog. Risks Hum. 63 , 325-33, (1995)

3-Chloro-2-methylpropene.

Rep. Carcinog. 12 , 100-1, (2011)

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293

Total 212, Current Page 1 of 22

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

MFCD00000953

EINECS 209-251-2

3-Chloro-2-methyl-1-propene

3-Chloro-2-methylprop-1-ene

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of 3-Chloro-2-methylpropene?

A: Boiling point of 3-Chloro-2-methylpropene is 72.4±9.0 °C at 760 mmHg.

Q: What is the molecular weight of 3-Chloro-2-methylpropene?

A: Molecular weight of 3-Chloro-2-methylpropene is 90.551.

Q: What are the downstream products of 3-Chloro-2-methylpropene?

A: Related downstream products(CAS) of 3-Chloro-2-methylpropene: 10500-86-4;10523-77-0;111719-00-7;10474-14-3;109930-20-3;40463-03-4;3290-53-7;300-57-2;42288-08-4;4911-54-0.

Q: What English synonyms does 3-Chloro-2-methylpropene have?

A: English synonyms of 3-Chloro-2-methylpropene: MFCD00000953, EINECS 209-251-2, 3-Chloro-2-methyl-1-propene, 3-Chloro-2-methylprop-1-ene.

Q: How is the water solubility of 3-Chloro-2-methylpropene?

A: Water solubility of 3-Chloro-2-methylpropene: 0.5 g/L (20 ºC).

Q: What is the safety information for 3-Chloro-2-methylpropene?

A: Safety information for 3-Chloro-2-methylpropene: S9-S16-S29-S36/37/39-S45-S61-S26.

Q: What is the SMILES notation of 3-Chloro-2-methylpropene?

A: SMILES notation of 3-Chloro-2-methylpropene is C=C(C)CCl.

Q: What are the upstream materials of 3-Chloro-2-methylpropene?

A: Related upstream materials(CAS) of 3-Chloro-2-methylpropene: 32670-93-2;115-11-7;628-56-8;78538-54-2;64-19-7;3100-04-7;7782-50-5;594-37-6.

Q: What is the InChIKey of 3-Chloro-2-methylpropene?

A: InChIKey of 3-Chloro-2-methylpropene is OHXAOPZTJOUYKM-UHFFFAOYSA-N.

Q: What is the LogP of 3-Chloro-2-methylpropene?

A: LogP of 3-Chloro-2-methylpropene is 2.20.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3-Chloro-2-methyl-1-propene
Price: Check
Purity: 97.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-Chloro-2-methylpropene
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU CHEM 563-47-3 3-Chloro-2-methylpropene
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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3-Chloro-2-methyl-1-propene

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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Precursor & DownStream

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3-Chloro-2-methyl-1-propeneBioassay

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.