Nucleophilic Phosphanylation of Fluoroaromatic Compounds with Carboxyl, Carboxymethyl, and Aminomethyl Functionalities− an Efficient Synthetic Route to …

M Hingst, M Tepper, O Stelzer

Index: Hingst, Martin; Tepper, Michael; Stelzer, Othmar European Journal of Inorganic Chemistry, 1998 , # 1 p. 73 - 82

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Citation Number: 6

Abstract

Abstract Chiral-and multiply-carboxylated phosphanes and phosphanyl derivatives of benzoic and phthalic acids (1− 9) are accessible in high yields by nucleophilic phosphanylation of potassium or lithium salts of commercially available fluorobenzoic and 3- fluorophthalic acids with Ph 2 PH, Ph 2 PK, PhPLi 2 Ph (K) P−(CH 2) 3− P (K) Ph in superbasic media (DMSO/KOH) or in THF and DME. The hitherto unknown ...