Synlett

Facile Preparation of Thiazoles from 1H-1-(1′-Alkynyl)-5-methyl-1, 2, 3-benziodoxathiole 3, 3-Dioxide with Thioamides

Y Ishiwata, H Togo

Index: Ishiwata, Yoshihide; Togo, Hideo Synlett, 2008 , # 17 p. 2637 - 2641

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Citation Number: 13

Abstract

Abstract Thiazoles were obtained in high yields by the reaction of 1H-1-(1′-alkynyl)-5- methyl-1, 2, 3-benziodoxathiole 3, 3-dioxides, which were easily prepared from the reaction of 1H-1-hydroxy-5-methyl-1, 2, 3-benziodoxathiole 3, 3-dioxide and 1-alkynes, with thioamides. Here, the co-product, potassium 2-iodo-5-methylbenzenesulfonate, was recovered quantitatively by simple filtration of the reaction mixture, and was regenerated ...