Tetrahedron

Application of chemoenzymatic hydrolysis in the synthesis of 2-monoacylglycerols

KM Whitten, A Makriyannis, SK Vadivel

Index: Whitten, Kyle M.; Makriyannis, Alexandros; Vadivel, Subramanian K. Tetrahedron, 2012 , vol. 68, # 27-28 p. 5422 - 5428

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Citation Number: 5

Abstract

The selective biocatalyzed synthesis of 2-monoacylglycerols (2-MAGs) through the use of commercially available immobilized Candida antarctica (Novozym435) and Rhizomucor miehei is explored. Reactions at room temperature result in the formation of a 2-MAG and a corresponding ethyl ester of the fatty acid with immobilized C. antarctica within 2h with yields ranging from 36% to 83%. Similar reaction conditions with immobilized R. miehei yielded ...