2-Palmitoylglycerol

Modify Date: 2024-01-02 13:39:51

2-Palmitoylglycerol Structure
2-Palmitoylglycerol structure
Common Name 2-Palmitoylglycerol
CAS Number 23470-00-0 Molecular Weight 330.50300
Density 0.969g/cm3 Boiling Point 460.6ºC at 760mmHg
Molecular Formula C19H38O4 Melting Point 68-70°C
MSDS USA Flash Point 150.8ºC

 Use of 2-Palmitoylglycerol


2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119[1].

 Names

Name 2-Palmitoyl-rac-glycerol
Synonym More Synonyms

 2-Palmitoylglycerol Biological Activity

Description 2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119[1].
Related Catalog
Target

CB1

In Vitro 2-Palmitoylglycerol (2-PG) modestly internalizes CB1 receptor on its own at concentrations as low as 300nM. 2-Palmitoylglycerol behaves as a very modest antagonist in depolarization-induced suppression of excitation (DSE)[1].
References

[1]. Natalia Murataeva, et al. Where's my entourage? The curious case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol. Pharmacol Res. 2016 Aug;110:173-180.

 Chemical & Physical Properties

Density 0.969g/cm3
Boiling Point 460.6ºC at 760mmHg
Melting Point 68-70°C
Molecular Formula C19H38O4
Molecular Weight 330.50300
Flash Point 150.8ºC
Exact Mass 330.27700
PSA 66.76000
LogP 4.36410
Index of Refraction 1.4434 (estimate)
Storage condition −20°C

 Safety Information

Hazard Codes Xi
Risk Phrases 43
Safety Phrases 36/37
RIDADR NONH for all modes of transport
HS Code 2915709000

 Synthetic Route

~96%

2-Palmitoylglycerol Structure

2-Palmitoylglycerol

CAS#:23470-00-0

Literature: Kim, Young-Ah; Park, Myoung-Soon; Kim, Young Hwan; Han, So-Yeop Tetrahedron, 2003 , vol. 59, # 16 p. 2921 - 2928

~79%

2-Palmitoylglycerol Structure

2-Palmitoylglycerol

CAS#:23470-00-0

Literature: Whitten, Kyle M.; Makriyannis, Alexandros; Vadivel, Subramanian K. Tetrahedron, 2012 , vol. 68, # 27-28 p. 5422 - 5428

~49%

2-Palmitoylglycerol Structure

2-Palmitoylglycerol

CAS#:23470-00-0

Literature: Han; Cho; Kim; Seo; Moon; Jhon Bioorganic and medicinal chemistry letters, 1999 , vol. 9, # 1 p. 59 - 64

~95%

2-Palmitoylglycerol Structure

2-Palmitoylglycerol

CAS#:23470-00-0

Literature: Schmid; Bornscheuer; Soumanou; McNeill JAOCS, Journal of the American Oil Chemists' Society, 1998 , vol. 75, # 11 p. 1527 - 1531

~%

Detail
Literature: Kharchafi, Ghizlane; Jerome, Francois; Adam, Isabelle; Pouilloux, Yannick; Barrault, Joel New Journal of Chemistry, 2005 , vol. 29, # 7 p. 928 - 934

~%

2-Palmitoylglycerol Structure

2-Palmitoylglycerol

CAS#:23470-00-0

Literature: Martin Journal of the American Chemical Society, 1953 , vol. 75, p. 5482

~%

2-Palmitoylglycerol Structure

2-Palmitoylglycerol

CAS#:23470-00-0

Literature: Boswinkel; Derksen; Van't Riet; Cuperus JAOCS, Journal of the American Oil Chemists' Society, 1996 , vol. 73, # 6 p. 707 - 711

 Customs

HS Code 2915709000
Summary 2915709000. palmitic acid and its salts and esters. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

2-Palmitoylglycerol
2-Palmitoylglycerol,2-Hydroxy-1-(hydroxymethyl)ethylhexadecanoicacidester
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