Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil

…, Y Li, T Gong, X Sun, Y Fu, Q He, Z Zhang

Index: Xuan, Zhang; Xing, Liu; Tao, Gong; Xun, Sun; Zhang, Zhi-Rong Acta Pharmacologica Sinica, 2012 , vol. 33, # 2 p. 279 - 288

Full Text: HTML

Citation Number: 4

Abstract

The blood brain barrier (BBB) represents the biggest challenge for therapeutic drugs to enter the brain. In our study, we selected chlorambucil (CHL), an alkylating agent, as the model therapeutic agent, and used scopine as a novel brain-targeting moiety. Here, we