Tetrahedron

A guideline for the arylation of positions 4 and 5 of thiazole via Pd-catalyzed cross-coupling reactions

J Hämmerle, M Schnürch, N Iqbal, MD Mihovilovic…

Index: Haemmerle, Johanna; Schnuerch, Michael; Iqbal, Naseer; Mihovilovic, Marko D.; Stanetty, Peter Tetrahedron, 2010 , vol. 66, # 40 p. 8051 - 8059

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Citation Number: 9

Abstract

The arylation of thiazoles in 4-and 5-position was investigated in detail. Suzuki–Miyaura and Stille cross-coupling reactions were tested using thiazoles either as halide or organometal species. The obtained results were critically compared to develop helpful guidelines for selection of the cross-coupling methodology with the best potential for good and reliable results for a given synthetic problem without the need for tedious optimization of reaction ...