Vilsmeier–Haack formylation of coumarin derivatives. A solvent dependent kinetic study

KC Rajanna, F Solomon, MM Ali…

Index: Rajanna; Solomon, Florence; Ali, Mir Moazzam; Sai Prakash International Journal of Chemical Kinetics, 1996 , vol. 28, # 12 p. 865 - 872

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Citation Number: 18

Abstract

Abstract A kinetic study of the reaction of coumarin derivatives with Vilsmeier-Haack (VH) reagent (1: 1 DMF-POCl 3) in various solvent media revealed second-order kinetics with a first-order in [Substrate] and first-order in [VH reagent]. The reaction rates altered nonlinearly with an increase in the dielectric constant of the medium and the data did not fit completely well with either Amis or Kirkwood's theories of ion (SINGLEBOND) dipole and dipole ( ...