Antiradiation compounds. 20. 1-Methylquinolinium (and pyridinium)-2-dithioacetic acid derivatives

…, RW Jones, PK Ghoshal, B Almassian

Index: Foye; Jones; Ghoshal; Almassian Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 57 - 62

Full Text: HTML

Citation Number: 14

Abstract

A new class of radiation-protective compounds has been found in the bis (methy1thio) and methylthio amino derivatives of 1-methylquinolinium-and 1-methylpyridinium-2-dithioacetic acids. The compounds gave good protection to mice VI. 1000-rad y-radiation in ip doses of 10 mg/kg or less, much lower than those required for the aminoalkyl thiols (-150-600 mg/kg). The dithioacetic acid zwitterions were prepared from the base-catalyzed reaction of ...