Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships

TP Culbertson, JP Sanchez, L Gambino…

Index: Culbertson, Townley P.; Sanchez, Joseph P.; Gambino, Laura; Sesnie, Josephine A. Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2270 - 2275

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Citation Number: 25

Abstract

Quinolone antibacterial agents continue to show promise of being an important class of therapeutically useful compounds.'Most of these agents, which have broad spectrum activity, are substituted at the 7-position by cyclic aliphatic amines (side chains), especially diamines such as piperazine. Notable examples are norfloxacin (la), ciprofloxacin (lb), enoxacin (IC), and ofloxacin (ld).