Beilstein journal of organic chemistry

Deoxygenative gem-difluoroolefination of carbonyl compounds with (chlorodifluoromethyl) trimethylsilane and triphenylphosphine

F Wang, L Li, C Ni, J Hu

Index: Wang, Fei; Li, Lingchun; Ni, Chuanfa; Hu, Jinbo Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 344 - 351

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Citation Number: 20

Abstract

Background: 1, 1-Difluoroalkenes cannot only be used as valuable precursors for organic synthesis, but also act as bioisosteres for enzyme inhibitors. Among various methods for their preparation, the carbonyl olefination with difluoromethylene phosphonium ylide represents one of the most straightforward methods. Results: The combination of (chlorodifluoromethyl) trimethylsilane (TMSCF 2 Cl) and triphenylphosphine (PPh 3) can ...