o-Nitrophenol

Modify Date: 2026-06-30 18:18:10

o-Nitrophenol Structure
o-Nitrophenol structure
 Common Name o-Nitrophenol
CAS Number 88-75-5 Molecular Weight 139.10900
Density 1.495 Boiling Point 214-216 °C
Molecular Formula C6H5NO3 Melting Point 43-45 °C
MSDS Chinese USA Flash Point 108 °C
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08		 Signal Word Danger

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2-nitrophenol
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.495
Boiling Point 214-216 °C
Melting Point 43-45 °C
Molecular Formula C6H5NO3
Molecular Weight 139.10900
Flash Point 108 °C
Exact Mass 139.02700
PSA 66.05000
LogP 1.82360
Vapour Pressure 1 mm Hg ( 49.3 °C)
Index of Refraction 1.5723 (50ºC)
InChIKey IQUPABOKLQSFBK-UHFFFAOYSA-N
SMILES O=[N+]([O-])c1ccccc1O
Stability Stable. Incompatible with strong bases, strong oxidizing agents.
Water Solubility 2 g/L (25 ºC)

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SM2100000
CHEMICAL NAME :
Phenol, o-nitro-
CAS REGISTRY NUMBER :
88-75-5
LAST UPDATED :
199710
DATA ITEMS CITED :
18
MOLECULAR FORMULA :
C6-H5-N-O3
MOLECULAR WEIGHT :
139.12
WISWESSER LINE NOTATION :
WNR BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
334 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPPAF Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. (Institut Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya Estonskoi SSR, Tallinn, USSR) V.8- 1972- Volume(issue)/page/year: 8,145,1972
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - coma
REFERENCE :
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881- Volume(issue)/page/year: 16,449,1896
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1297 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433) Volume(issue)/page/year: TR-72-62,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
378 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,868,1975
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,120,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,675,1986
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,120,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>7940 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - changes in motor activity (specific assay)
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,74,1990
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,120,1959
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - coma
REFERENCE :
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881- Volume(issue)/page/year: 16,449,1896
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,120,1959 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 50950 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 132 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 50950 No. of Facilities: 6 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 80 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
Hazard Codes Xn:Harmful
Risk Phrases R20/21/22;R33
Safety Phrases S26-S61-S45-S36/37-S16-S7-S36
RIDADR UN 1663 6.1/PG 3
WGK Germany 2
RTECS SM2100000
Packaging Group III
Hazard Class 6.1
HS Code 2908999090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2908999090
Summary 2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Articles49

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

cIEF for rapid pKa determination of small molecules: a proof of concept.

Eur. J. Pharm. Sci. 63 , 14-21, (2014)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) w...

Highly sensitive electrochemical biosensor for bisphenol A detection based on a diazonium-functionalized boron-doped diamond electrode modified with a multi-walled carbon nanotube-tyrosinase hybrid film.

Biosens. Bioelectron. 74 , 830-5, (2015)

A highly sensitive electrochemical biosensor for the detection of Bisphenol A (BPA) in water has been developed by immobilizing tyrosinase onto a diazonium-functionalized boron doped diamond electrode...

Antimicrobial activities and action mechanism studies of transportan 10 and its analogues against multidrug-resistant bacteria.

J. Pept. Sci. 21 , 599-607, (2015)

The increased emergence of multidrug-resistant bacteria is perceived as a critical public health threat, creating an urgent need for the development of novel classes of antimicrobials. Cell-penetratin...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2-nitro-1-hydroxybenzene
o-Nitrofenol
Phenol,o-nitro
2-nitro-pheno
ortho-nitrophenol
EINECS 201-857-5
O-NITROPHENOL
MFCD00011688
o-nitro-pheno
2--nitrophenol
2-Nitrophenol
o-hydroxynitrobenzene
2-Nitrylphemol
2-Hydroxynitrobenzene
Phenol,2-nitro
o-nitrophenol[qr]

 o-Nitrophenol | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of 2-nitrophenol?
A: CAS number of 2-nitrophenol is 88-75-5.
Q: What English synonyms does 2-nitrophenol have?
A: English synonyms of 2-nitrophenol: 2-nitro-1-hydroxybenzene, o-Nitrofenol, Phenol,o-nitro, 2-nitro-pheno, ortho-nitrophenol, EINECS 201-857-5, O-NITROPHENOL, MFCD00011688, o-nitro-pheno, 2--nitrophenol, 2-Nitrophenol, o-hydroxynitrobenzene, 2-Nitrylphemol, 2-Hydroxynitrobenzene, Phenol,2-nitro, o-nitrophenol[qr].
Q: What are the downstream products of 2-nitrophenol?
A: Related downstream products(CAS) of 2-nitrophenol: 10514-62-2;104809-26-9;105337-21-1;111331-20-5;1086390-21-7;1079-56-7;50353-00-9;37682-29-4;32278-16-3;5274-70-4.
Q: What is the molecular formula of 2-nitrophenol?
A: Molecular formula of 2-nitrophenol is C6H5NO3.
Q: What is the boiling point of 2-nitrophenol?
A: Boiling point of 2-nitrophenol is 214-216 °C.
Q: What is the InChIKey of 2-nitrophenol?
A: InChIKey of 2-nitrophenol is IQUPABOKLQSFBK-UHFFFAOYSA-N.
Q: What is the molecular weight of 2-nitrophenol?
A: Molecular weight of 2-nitrophenol is 139.10900.
Q: What are the upstream materials of 2-nitrophenol?
A: Related upstream materials(CAS) of 2-nitrophenol: 5570-19-4;88-73-3;108-95-2;56182-22-0;577-19-5;158813-51-5;4560-41-2;609-73-4;25458-47-3;602-00-6.
Q: What is the melting point of 2-nitrophenol?
A: Melting point of 2-nitrophenol is 43-45 °C.
Q: What is the English name of 2-nitrophenol?
A: The English name of 2-nitrophenol is 2-nitrophenol.

 o-Nitrophenolfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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Chemsrc provides o-Nitrophenol(CAS#:88-75-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of o-Nitrophenol are included as well.>> amp version: o-Nitrophenol

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