The Journal of organic chemistry

Transition-Metal-Free Indirect Friedländer Synthesis of Quinolines from Alcohols†

R Martínez, DJ Ramón, M Yus

Index: Martinez, Ricardo; Ramon, Diego J.; Yus, Miguel Journal of Organic Chemistry, 2008 , vol. 73, # 24 p. 9778 - 9780

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Citation Number: 82

Abstract

Several different strategies for the preparation of substituted quinolines are known, with the Friedländer annulation being the most simple, straightforward, and widely used approach.(8) Nevertheless, most of the synthetic approaches reported so far suffer from need of high temperatures or harsh reaction conditions, low yields, use of hazardous and often expensive catalysts, and problems associated with the storage of carbonyl reagents. Moreover, the usual solvents ...