Copper??Catalyzed N??Alkylation of Sulfonamides with Benzylic Alcohols: Catalysis and Mechanistic Studies

…, D Goerdes, K Thurow, M Beller, Y Deng

Index: Cui, Xinjiang; Shi, Feng; Tse, Man Kin; Goerdes, Dirk; Thurow, Kerstin; Beller, Matthias; Deng, Youquan Advanced Synthesis and Catalysis, 2009 , vol. 351, # 17 p. 2949 - 2958

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Citation Number: 51

Abstract

Abstract The N-alkylation of sulfonamides with alcohols is efficiently performed in the presence of easily available copper catalysts via hydrogen borrowing methodology. Applying a copper acetate/potassium carbonate system the reaction of sulfonamides and alcohols gave the corresponding secondary amines in excellent yield. In situ HR-MS analysis indicated that bissulfonylated amines are formed under air atmosphere, which act ...