Tetrahedron letters

High yield acyl anion transfer reactions: nucleophilic acylation of aldehydes

D Seyferth, RM Weinstein, WL Wang, RC Hui

Index: Seyferth, Dietmar; Weinstein, Robert M.; Wang, Wei-Liang; Hui, Richard C. Tetrahedron Letters, 1983 , vol. 24, # 45 p. 4907 - 4910

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Citation Number: 27

Abstract

Abstract Aldehydes may be acylated to give R'CH (ON) C (O) R in good yield by the RLi/CO in situ procedure at very low temperatures. Examples are given of ketone acylations which demonstrate the advantages of 1: 1 RLi/substrate stoichiometry and the use of lower (− 135 C) temperature.