e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Studies on v-triazoles. 9. Antiallergic 4, 9-dihydro-4, 9-dioxo-1H-naphtho [2, 3-d]-v-triazoles

DR Buckle, H Smith, BA Spicer…

Index: Buckle; Smith; Spicer; Tedder Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 714 - 719

Full Text: HTML

Citation Number: 10

Abstract

12, R,(R,)= Me; 14, R,= R,= H 15, R,= Me; R,= H 16, R,= R,= Me Rz (Ri)= H 13, R,= R,= Me choice being largely dependent on the position and type of substitution. The parent compound, 14, was prepared from 2, 3-dichloronaphthoquinone by the method of Fieser and Martin: and an analogous procedure was used for the 6-methyl and 6, 7-dimethyl homologues, 15 and 16, respectively. Thus, bromination of the naphthoquinones 4 and 5 ( ...

5-methylsulfanyl-2H-benzo[f]benzotriazole-4,9-dione Structure

5-methylsulfany...

~77%

5-methylsulfinyl-2H-benzo[f]benzotriazole-4,9-dione Structure

5-methylsulfiny...

Learn More

5-methylsulfanyl-2H-benzo[f]benzotriazole-4,9-dione Structure

5-methylsulfany...

~59%

5-methylsulfonyl-2H-benzo[f]benzotriazole-4,9-dione Structure

5-methylsulfony...

Learn More

1-[(4-methoxyphenyl)methyl]-1H,4H,9H-naphtho[2,3-d][1,2,3]triazole-4,9-dione Structure

1-[(4-methoxyph...

~90%

2H-benzo[f]benzotriazole-4,9-dione Structure

2H-benzo[f]benz...

Learn More

1,4-naphthoquinone Structure

1,4-naphthoquinone

~%

2H-benzo[f]benzotriazole-4,9-dione Structure

2H-benzo[f]benz...

Learn More

N-(3-amino-1,4-dihydroxynaphthalen-2-yl)acetamide Structure

N-(3-amino-1,4-...

~%

2H-benzo[f]benzotriazole-4,9-dione Structure

2H-benzo[f]benz...

Learn More

1,4-Naphthalenedione,6,7-dimethyl Structure

1,4-Naphthalene...

~76%

2,3-dibromo-6,7-dimethyl-naphthalene-1,4-dione Structure

2,3-dibromo-6,7...

Learn More

Ethanoic anhydride Structure

Ethanoic anhydride

3-amino-2-bromo-6,7-dimethyl-naphthalene-1,4-dione Structure

3-amino-2-bromo...

~68%

N-(3-bromo-6,7-dimethyl-1,4-dioxo-naphthalen-2-yl)acetamide Structure

N-(3-bromo-6,7-...

Learn More

1,4-Naphthalenedione,6,7-dimethyl Structure

1,4-Naphthalene...

~%

N-(3-bromo-6,7-dimethyl-1,4-dioxo-naphthalen-2-yl)acetamide Structure

N-(3-bromo-6,7-...

Learn More

2,3-dibromo-6,7-dimethyl-naphthalene-1,4-dione Structure

2,3-dibromo-6,7...

~%

N-(3-bromo-6,7-dimethyl-1,4-dioxo-naphthalen-2-yl)acetamide Structure

N-(3-bromo-6,7-...

Learn More

2-acetamido-3-amino-6,7-dimethyl-1,4-naphthoquinone Structure

2-acetamido-3-a...

~%

6,7-dimethyl-2H-benzo[f]benzotriazole-4,9-dione Structure

6,7-dimethyl-2H...

Learn More

4,9-dihydro-6,7-dimethyl-4,9-dioxo-1-(4-methoxybenzyl)naphtho[2,3-d]-v-triazole Structure

4,9-dihydro-6,7...

~61%

6,7-dimethyl-2H-benzo[f]benzotriazole-4,9-dione Structure

6,7-dimethyl-2H...

Learn More

1,4-Naphthalenedione,6,7-dimethyl Structure

1,4-Naphthalene...

~%

6,7-dimethyl-2H-benzo[f]benzotriazole-4,9-dione Structure

6,7-dimethyl-2H...

Learn More

3-amino-2-bromo-6,7-dimethyl-naphthalene-1,4-dione Structure

3-amino-2-bromo...

~%

6,7-dimethyl-2H-benzo[f]benzotriazole-4,9-dione Structure

6,7-dimethyl-2H...

Learn More

2,3-dibromo-6,7-dimethyl-naphthalene-1,4-dione Structure

2,3-dibromo-6,7...

~%

6,7-dimethyl-2H-benzo[f]benzotriazole-4,9-dione Structure

6,7-dimethyl-2H...

Learn More

N-(3-bromo-6,7-dimethyl-1,4-dioxo-naphthalen-2-yl)acetamide Structure

N-(3-bromo-6,7-...

~%

6,7-dimethyl-2H-benzo[f]benzotriazole-4,9-dione Structure

6,7-dimethyl-2H...

Learn More

N-(3-amino-1,4-dihydroxy-6,7-dimethylnaphthalen-2-yl)acetamide Structure

N-(3-amino-1,4-...

~%

6,7-dimethyl-2H-benzo[f]benzotriazole-4,9-dione Structure

6,7-dimethyl-2H...

Learn More

2H-benzo[f]benzotriazole-4,9-dione Structure

2H-benzo[f]benz...

~1%

6-nitro-2H-benzo[f]benzotriazole-4,9-dione Structure

6-nitro-2H-benz...

5-nitro-2H-benzo[f]benzotriazole-4,9-dione Structure

5-nitro-2H-benz...

Learn More

1,4-naphthoquinone Structure

1,4-naphthoquinone

~%

5-nitro-2H-benzo[f]benzotriazole-4,9-dione Structure

5-nitro-2H-benz...

Learn More

N-(3-amino-1,4-dihydroxynaphthalen-2-yl)acetamide Structure

N-(3-amino-1,4-...

~%

5-nitro-2H-benzo[f]benzotriazole-4,9-dione Structure

5-nitro-2H-benz...

Learn More

1-[(4-methoxyphenyl)methyl]-1H,4H,9H-naphtho[2,3-d][1,2,3]triazole-4,9-dione Structure

1-[(4-methoxyph...

~%

5-nitro-2H-benzo[f]benzotriazole-4,9-dione Structure

5-nitro-2H-benz...

Learn More

1,4-Naphthalenedione,6,7-dimethyl Structure

1,4-Naphthalene...

~%

3-amino-2-bromo-6,7-dimethyl-naphthalene-1,4-dione Structure

3-amino-2-bromo...

Learn More

2H-benzo[f]benzotriazole-4,9-dione Structure

2H-benzo[f]benz...

~0%

6-nitro-2H-benzo[f]benzotriazole-4,9-dione Structure

6-nitro-2H-benz...

5-nitro-2H-benzo[f]benzotriazole-4,9-dione Structure

5-nitro-2H-benz...

Learn More

1,4-naphthoquinone Structure

1,4-naphthoquinone

~%

6-nitro-2H-benzo[f]benzotriazole-4,9-dione Structure

6-nitro-2H-benz...

Learn More

N-(3-amino-1,4-dihydroxynaphthalen-2-yl)acetamide Structure

N-(3-amino-1,4-...

~%

6-nitro-2H-benzo[f]benzotriazole-4,9-dione Structure

6-nitro-2H-benz...

Learn More

1-[(4-methoxyphenyl)methyl]-1H,4H,9H-naphtho[2,3-d][1,2,3]triazole-4,9-dione Structure

1-[(4-methoxyph...

~%

6-nitro-2H-benzo[f]benzotriazole-4,9-dione Structure

6-nitro-2H-benz...

Learn More