Iron (III)??Catalyzed Cyclization of Alkynyl Aldehyde Acetals: Experimental and Computational Studies

T Xu, Q Yang, D Li, J Dong, Z Yu…

Index: Xu, Tongyu; Yang, Qin; Li, Dongpo; Dong, Jinhua; Yu, Zhengkun; Li, Yuxue Chemistry - A European Journal, 2010 , vol. 16, # 30 p. 9264 - 9272

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Abstract

Abstract FeCl 3⋅ 6 H 2 O-and FeBr 3-catalyzed Prins cyclization/halogenation of alkynyl aldehyde acetals has been realized with acetyl chloride or bromide as halogen source in dichloromethane to afford 2-(1-halobenzylidene or alkylidene)-substituted five-membered carbo-and heterocycles, and thus provides an alternative route for vinylic C [BOND] Cl and C [BOND] Br bond formation. Five-to eight-membered cyclic enones were efficiently ...