Selective hydrolysis-decarboxylation of ethyl 1, 4-dimethyl-3-ethoxycarbonyl-1H-pyrrole-2-acetate

GP Stahly, EM Marlett, GE Nelson

Index: Stahly, G. P.; Marlett, E. M.; Nelson, G. E. Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4423 - 4426

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Citation Number: 6

Abstract

Treatment of compound 2, 3, or 4 under the conditions described also afforded ester 5. Thus the reaction pathway can be envisioned as a series of hydrolysis-esterification equilibria followed by decarboxylations to produce compound 5 and the completely decarboxylated pyrrole 7 (Scheme I). To confii this sequence, a mixture of diester 1, sulfuric acid, ethanol, and water maintained at 60" C was sampled regularly, and the samples were analyzed by ...