A new leaving group in nucleophilic aromatic substitution reactions (SNAr)

M Bakavoli, M Pordel, M Rahimizadeh…

Index: Bakavoli, Mehdi; Pordel, Mehdi; Rahimizadeh, Mohammad; Jahandari, Pooneh Journal of Chemical Research, 2008 , # 8 p. 432 - 433

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Citation Number: 5

Abstract

Nucleophilic aromatic substitution of a 2, 4-dinitrophenyl substituted pyrazole 1 with primary amines leads to substitution of the pyrazolo substituent. In these nucleophilic aromatic substitution reactions (SNAr), 5-amino-1H-4-pyrazolecarbonitrile (3) acts as a new leaving group.

~81%

~72%

~90%

~89%

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