RSC Advances

Synthesis of European pharmacopoeial impurities A, B, C, and D of cabergoline

J Wagger, A Požes, F Požgan

Index: Wagger, Jernej; Pozes, Aljaz; Pozgan, Franc RSC Advances, 2013 , vol. 3, # 45 p. 23146 - 23156

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Citation Number: 2

Abstract

For the use of analytics, European pharmacopoeial impurities A, B, C, and D of cabergoline were synthesized. Ergocryptine was chosen as a starting material and synthesis was accomplished via two approaches, different in length and stereochemical outcome. A longer, indirect approach was realized through otherwise problematic oxidations of the 9, 10- dihidrolysergol derivative, to the corresponding aldehyde and carboxylic acid. This was ...