Efficient and Facile Three-Component Reaction for the Synthesis of 2-Amine-4, 6-diarylpyrimidine Under Solvent-Free Conditions

Q Zhuang, HX Han, S Wang, S Tu…

Index: Zhuang, Qiya; Han, HongXia; Wang, Suhui; Tu, Shuajiang; Rong, Liangce Synthetic Communications, 2009 , vol. 39, # 3 p. 516 - 522

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Citation Number: 7

Abstract

Abstract An efficient and convenient multicomponent reaction for the preparation of 2-amine- 4, 6-diarylpyrimidine by aromatic aldehydes, aromatic ketones, and guanidine carbonate in the presence of sodium hydroxide under solvent-free conditions is reported. The short reaction time coupled with the simplicity of the reaction procedure make this method one of the most efficient methods for the synthesis of this class of compounds.