ACS combinatorial science

One-pot access to a library of structurally diverse nicotinamide derivatives via a three-component formal aza [3+ 3] cycloaddition

G Tenti, MT Ramos, JC Menéndez

Index: Tenti, Giammarco; Teresa Ramos; Carlos Menendez ACS Combinatorial Science, 2012 , vol. 14, # 10 p. 551 - 557

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Citation Number: 22

Abstract

The three-component formal [3+ 3] aza-annulation between chalcones, β-ketoamides, and ammonium acetate in the presence of CAN as a Lewis acid affords good to excellent yields of highly substituted nicotinamides or their fused derivatives. This transformation leads to the formation of one C–C and two C–N bonds in a single synthetic operation and involves up to five individual steps.