Sterically hindered triacylglycerol analogues as potent inhibitors of human digestive lipases

V Constantinou??Kokotou, V Magrioti…

Index: Constantinou-Kokotou, Violetta; Magrioti, Victoria; Verger, Robert Chemistry - A European Journal, 2004 , vol. 10, # 5 p. 1133 - 1140

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Citation Number: 7

Abstract

Abstract A novel class of inhibitors of human digestive lipases have been developed. Various sterically hindered triacylglycerols based on 2-methyl-and 2-butylglycerol, and/or 2- methyl fatty acids were synthesized. The triacylglycerol analogues were tested for their ability to form stable monomolecular films at the air/water interface by recording their surface- pressure/molecular-area compression isotherms. The inhibition of human pancreatic and ...