Antibody bait and switch catalysis: a survey of antigens capable of inducing abzymes with acyl-transfer properties

…, MI Weinhouse, T Danon, KA Pacelli…

Index: Janda, Kim D.; Weinbouse, Michael I.; Danon, Tami; Pacelli, Karen A.; Schloeder, Diane M. Journal of the American Chemical Society, 1991 , vol. 113, # 14 p. 5427 - 5434

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Citation Number: 73

Abstract

Abstract: Antibodies have been shown to catalyze acyl-transfer reactions. Various antigens have been applied to these hydrolytic reactions, but typically all encompass the same theme of incorporating a monoanionic phosphonate/phosphonamidate. To expand the scope and capabilities of these abzymes, we have directed our attention toward new strategies in antigen design. One method, which we have termed" bait and switch" catalysis, uses ...