Synthesis and Evaluation of Novel Phenylethanolamine Derivatives containing Acetanilides as Potent and Selective. BETA. 3-Adrenergic Receptor Agonists

T Maruyama, K Onda, M Hayakawa, T Suzuki…

Index: Maruyama, Tatsuya; Onda, Kenichi; Hayakawa, Masahiko; Suzuki, Takayuki; Kimizuka, Tetsuya; Matsui, Tetsuo; Takasu, Toshiyuki; Nagase, Itsuro; Hamada, Noritaka; Ohta, Mitsuaki Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 4 p. 533 - 545

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Citation Number: 9

Abstract

In the search for potent and selective human β3-adrenergic receptor (AR) agonists as potential pharmacotherapies for the treatment of obesity and non-insulin dependent (type II) diabetes, we prepared a novel series of phenylethanolamine derivatives containing acetanilides and evaluated their biological activities at the human β3-, β2-, and β1-ARs. Among these compounds, the 6-amino-2-pyridylacetanilide (36b), 2-amino-5- ...