e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Facile Room-Temperature MgBr2· OEt2-Catalyzed Thiolysis of Epoxides Under Solvent-Free Conditions
MM Mojtahedi, MS Abaee, M Bolourtchian…
Index: Mojtahedi, Mohammad M.; Abaee, M. Saeed; Bolourtchian, Mohammad; Abbasi, Hassan Phosphorus, Sulfur and Silicon and the Related Elements, 2007 , vol. 182, # 4 p. 905 - 910
Solvent-free ring opening of 1, 2-epoxides with aromatic and aliphatic thiols under 1 mol% magnesium bromide ethyl etherate catalysis affords rapid formation of β-hydroxy sulfides at ambient temperature with excellent yields. Nucleophilic attack of the thiols occurs regioselectively at the less hindered position of the epoxides.
