Tetrahedron

Rongalite® promoted highly regioselective synthesis of β-hydroxy sulfides by ring opening of epoxides with disulfides

W Guo, J Chen, D Wu, J Ding, F Chen, H Wu

Index: Guo, Wenxue; Chen, Jiuxi; Wu, Dengze; Ding, Jinchang; Chen, Fan; Wu, Huayue Tetrahedron, 2009 , vol. 65, # 27 p. 5240 - 5243

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Citation Number: 32

Abstract

Rongalite® promotes cleavage of disulfides generating thiolate anions that then undergo facile ring opening of epoxides in the presence of K2CO3 to afford α-addition products 3 with good to excellent yields. The important features of this methodology are broad substrates scope, high yielding, reasonably rapid reaction rate, high regioselectivity and no requirement of metal catalysts. It should be noted that the thiolate anion attacks the ...