Novel ZnX2-Modulated Pd/C and Pt/C Catalysts for Chemoselective Hydrogenation and Hydrogenolysis of Halogen-Substituted Nitroarenes, Alkenes, Benzyl Ethers, …

G Wu, M Huang, M Richards, M Poirier, X Wen…

Index: Wu, George; Huang, Mingsheng; Richards, Monique; Poirier, Marc; Wen, Xin; Draper, Richard W. Synthesis, 2003 , # 11 p. 1657 - 1660

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Citation Number: 26

Abstract

Recently, we have reported the first example of a ZnBr 2 -modulated chemoselective hydrogenolysis of a benzyl ether in the total synthesis of a cholesterol absorption inhibitor. [10] As shown in Scheme [1] , the use of 10% of commercially available palladium on carbon resulted in 4.7% (HPLC normalization) of des-chloro by-product, an impurity that was very difficult to purge out by either crystallization or chromatography. Addition of a small amount of acetic acid did not ...