A Convenient and Practical Synthesis of Anisoles and Deuterated Anisoles by Palladium??Catalyzed Coupling Reactions of Aryl Bromides and Chlorides

S Gowrisankar, H Neumann…

Index: Gowrisankar, Saravanan; Neumann, Helfried; Beller, Matthias Chemistry - A European Journal, 2012 , vol. 18, # 9 p. 2498 - 2502

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Citation Number: 19

Abstract

In recent years, palladium-and copper-catalyzed crosscoupling reactions have become useful tools for the synthesis of (hetero) aryl ethers.[1–3] Due to the presence of aromatic ether bonds in numerous natural products, pharmaceuticals, fragrances, cosmetics, and polymers,[4] further developments of efficient CÀO bond-forming reactions are of continuing interest for organic chemistry. In particular, methyl (hetero) aryl ethers (anisoles) represent ...

 Related Synthetic Route
Methanol Structure

67-56-1

Methanol

4-Bromotoluene Structure

106-38-7

4-Bromotoluene

~68%

4-Methylanisole Structure

104-93-8

4-Methylanisole

2-Bromopyridine Structure

109-04-6

2-Bromopyridine

Methanol Structure

67-56-1

Methanol

~82%

2-Methoxypyridine Structure

1628-89-3

2-Methoxypyridine

Methanol Structure

67-56-1

Methanol

1-(4-Bromophenyl)ethanone Structure

99-90-1

1-(4-Bromopheny...

~86%

Acetanisole Structure

100-06-1

Acetanisole

Methanol Structure

67-56-1

Methanol

1-(4-Chlorophenyl)ethanone Structure

99-91-2

1-(4-Chlorophen...

~82%

Acetanisole Structure

100-06-1

Acetanisole

Methanol Structure

67-56-1

Methanol

3-Bromobenzotrifluoride Structure

401-78-5

3-Bromobenzotri...

~83%

3-(Trifluoromethyl)anisole Structure

454-90-0

3-(Trifluoromet...

2,6-Dibromopyridine Structure

626-05-1

2,6-Dibromopyridine

Methanol Structure

67-56-1

Methanol

~76%

2,6-Dimethoxypyridine Structure

6231-18-1

2,6-Dimethoxypy...

Methanol Structure

67-56-1

Methanol

3-Bromobenzonitrile Structure

6952-59-6

3-Bromobenzonitrile

~58%

3-Methoxybenzonitrile Structure

1527-89-5

3-Methoxybenzon...

Methanol Structure

67-56-1

Methanol

m-chlorophenylacetylene Structure

766-83-6

m-chlorophenyla...

~53%

3-Methoxybenzonitrile Structure

1527-89-5

3-Methoxybenzon...

Methanol Structure

67-56-1

Methanol

4-Bromo-3-methyl-anisole Structure

27060-75-9

4-Bromo-3-methy...

~59%

2,5-dimethoxytoluene Structure

24599-58-4

2,5-dimethoxytoluene

Methanol Structure

67-56-1

Methanol

1-Bromo-2-(1-Methylethyl)Benzene Structure

7073-94-1

1-Bromo-2-(1-Me...

~63%

Benzene,1-methoxy-2-(1-methylethyl)- Structure

2944-47-0

Benzene,1-metho...

3-Bromopyridine Structure

626-55-1

3-Bromopyridine

Methanol Structure

67-56-1

Methanol

~78%

3-Methoxypyridine Structure

7295-76-3

3-Methoxypyridine


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