Rhodium-Catalyzed Reductive Decyanation of Nitriles Using Hydrosilane as a Reducing Agent: Scope, Mechanism and Synthetic Application

…, R Nakamura, Y Kita, N Chatani

Index: Tobisu, Mamoru; Nakamura, Ryo; Kita, Yusuke; Chatani, Naoto Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 3 p. 582 - 587

Full Text: HTML

Citation Number: 31

Abstract

Abstract A rhodium-catalyzed reductive cleavage reaction of carbon-cyano bonds is developed using hydrosilane as a mild reducing agent. A wide range of nitriles, including aryl, benzyl, and-hydrogen containing alkyl cyanides are applicable to this decyanation reaction. The method is also applicable to organic synthesis, in which benzyl cyanide is used as a benzyl anion equivalent and a cyano group functions as a removable ortho- ...