Tetrahydropyrrolo [1, 2-a] quinoxalines and tetrahydropyrrolo [1, 2-a] pyrido [3, 2-a] pyrazines: vascular smooth muscle relaxants and antihypertensive agents

M Abou-Gharbia, ME Freed, RJ McCaully…

Index: Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746

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Citation Number: 12

Abstract

A series of tetrahydropyrrolo [1, 2-a] quinoxalines and tetrahydropyrrolo [1, 2-a] pyrido [3, 2- a] pyrazines were synthesized and tested for their ability to relax K+-depolarized aortic smooth muscle and antihypertensive activity. It was shown that compounds producing the most relaxation of aortic smooth muscle (54 (2, 6-dimethoxyphenyl) methyl]-1, 2, 3, 3a- tetrahydropyrrolo [l, 2-a] quinoxalin-4 (5~)-on~ and 5-[(2, 6-dimethoxyphenyl) methyl]-5, 6, ...