Proline

Modify Date: 2026-06-30 22:07:08

Proline Structure
Proline structure
Common Name Proline
CAS Number 147-85-3 Molecular Weight 115.131
Density 1.2±0.1 g/cm3 Boiling Point 252.2±33.0 °C at 760 mmHg
Molecular Formula C5H9NO2 Melting Point 228 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 106.3±25.4 °C

 Use of Proline


L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name L-proline
Synonym More Synonyms

 Proline Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
Related Catalog
Target

Human Endogenous Metabolite

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.2±0.1 g/cm3
Boiling Point 252.2±33.0 °C at 760 mmHg
Melting Point 228 °C (dec.)(lit.)
Molecular Formula C5H9NO2
Molecular Weight 115.131
Flash Point 106.3±25.4 °C
Exact Mass 115.063332
PSA 49.33000
LogP -0.57
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.487
Water Solubility soluble

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TW3584000
CHEMICAL NAME :
Proline, L-
CAS REGISTRY NUMBER :
147-85-3
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C5-H9-N-O2
MOLECULAR WEIGHT :
115.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81957 No. of Facilities: 53 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 750 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81957 No. of Facilities: 762 (estimated) No. of Industries: 4 No. of Occupations: 14 No. of Employees: 18391 (estimated) No. of Female Employees: 13943 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TW3584000
HS Code 2933990090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles386

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Mechanism of chemical activation of sodium chloride in the presence of amino acids.

Food Chem. 166 , 301-8, (2014)

Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indi...

Metabolic network capacity of Escherichia coli for Krebs cycle-dependent proline hydroxylation.

Microb. Cell Fact. 14 , 108, (2015)

Understanding the metabolism of the microbial host is essential for the development and optimization of whole-cell based biocatalytic processes, as it dictates production efficiency. This is especiall...

Injectable microcarriers as human mesenchymal stem cell support and their application for cartilage and degenerated intervertebral disc repair.

Eur. Cell. Mater. 29 , 70-80; discujssion 80-1, (2015)

Degeneration of the intervertebral disc (IVD) is a progressive and chronic process, and the high incidence of discogenic disorders calls for new therapeutic approaches, such as cell-based therapies us...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

(-)-Proline
BYL719
Proline
(-)-(S)-proline
(2S)-proline
pyrrolidine-2-carbonic acid
(2S)-2-Pyrrolidinecarboxylic acid
(S)-2-Carboxypyrrolidine
(-)-2-Pyrrolidinecarboxylic acid
2-Pyrrolidinecarboxylic acid
(−)-proline
(S)-proline
EINECS 210-189-3
2-Pyrrolidinecarboxylicacid
L(-)-Proline
(2S)-pyrrolidine-2-carboxylic acid
MFCD00064318
(−)-2-pyrrolidinecarboxylic acid
(−)-(S)-proline
(S)-(-)-Pyrrolidine-2-carboxylic acid
L-a-Pyrrolidinecarboxylic Acid
(S)-(-)-Proline
(l)-proline
l-Pro
QCR-1
(S)-Pyrrolidine-2-carboxylic acid,L-Proline
EINECS 205-702-2
L-(-)-proline
L-pyrrolidine-2-carboxylic acid
(S)-Pyrrolidine-2-carboxylic acid

 Proline | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the upstream materials of L-proline?
A: Related upstream materials(CAS) of L-proline: 1148-11-4;1319113-56-8;15761-39-4;610299-77-9;344-25-2;439912-48-8;110637-44-0;91237-84-2;7531-52-4.
Q: What is the LogP of L-proline?
A: LogP of L-proline is -0.57.
Q: What is the molecular formula of L-proline?
A: Molecular formula of L-proline is C5H9NO2.
Q: What is the CAS number of L-proline?
A: CAS number of L-proline is 147-85-3.
Q: What is the melting point of L-proline?
A: Melting point of L-proline is 228 °C (dec.)(lit.).
Q: What is the safety information for L-proline?
A: Safety information for L-proline: S24/25.
Q: What is the polar surface area (PSA) of L-proline?
A: Polar surface area (PSA) of L-proline is 49.33000.
Q: What are the downstream products of L-proline?
A: Related downstream products(CAS) of L-proline: 103238-71-7;105099-19-2;110637-44-0;475-11-6;36976-98-4;31795-93-4;83528-04-5;33305-75-8;3304-59-4;5768-79-6.
Q: What are the uses of L-proline?
A: Main uses of L-proline: L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
Q: What is the boiling point of L-proline?
A: Boiling point of L-proline is 252.2±33.0 °C at 760 mmHg.

 Prolinefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
BioBioPha
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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