Tetrahedron

L-aspartic acid bis (trimethylsilyl) ester: a convenient starting material for the acylation of L-aspartic acid.

AM Castano, AM Echavarren

Index: Castano, Ana M.; Echavarren, Antonio M. Tetrahedron, 1992 , vol. 48, # 16 p. 3377 - 3384

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Citation Number: 8

Abstract

Reaction of L-aspartic acid with excess of bis (trimethylsilyl) amine under reflux provides optically pure L-aspartic acid bis (trimethylsilyl) ester in quantitative yield. This silyl ester reacts with a variety of acylating reagens in tetrahydrofuran to give N-protected aspartic

~65%

~91%

~89%

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