Ruthenium NHC catalyzed highly asymmetric hydrogenation of benzofurans

N Ortega, S Urban, B Beiring…

Index: Ortega, Nuria; Urban, Slawomir; Beiring, Bernhard; Glorius, Frank Angewandte Chemie - International Edition, 2012 , vol. 51, # 7 p. 1710 - 1713

Full Text: HTML

Citation Number: 75

Abstract

Asymmetric hydrogenation of aromatic and heteroaromatic compounds is one of the most straightforward ways for the synthesis of saturated or partially saturated cyclic molecules, which are present in many biologically active compounds.[1] Starting from the pioneering work of Murata and co-workers in 1987,[2] who obtained enantiomeric excess in the hydrogenation of 2-methylquinoxaline, impressive advances have been made in the ...