Coumarone

Modify Date: 2024-01-02 19:48:34

Coumarone Structure
Coumarone structure
 Common Name Coumarone
CAS Number 271-89-6 Molecular Weight 118.133
Density 1.1±0.1 g/cm3 Boiling Point 174.0±0.0 °C at 760 mmHg
Molecular Formula C8H6O Melting Point -18ºC
MSDS Chinese USA Flash Point 56.1±0.0 °C
Symbol GHS02 GHS08
GHS02, GHS08		 Signal Word Warning

 Names

Name 1-benzofuran
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 174.0±0.0 °C at 760 mmHg
Melting Point -18ºC
Molecular Formula C8H6O
Molecular Weight 118.133
Flash Point 56.1±0.0 °C
Exact Mass 118.041862
PSA 13.14000
LogP 2.67
Vapour Pressure 1.7±0.3 mmHg at 25°C
Index of Refraction 1.600
Water Solubility insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DF6423800
CHEMICAL NAME :
Benzofuran
CAS REGISTRY NUMBER :
271-89-6
BEILSTEIN REFERENCE NO. :
0107704
LAST UPDATED :
199710
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C8-H6-O
MOLECULAR WEIGHT :
118.14
WISWESSER LINE NOTATION :
T56 BOJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 gm/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
16250 mg/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in both tubules and glomeruli
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32500 mg/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
437 mg/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
61800 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
30900 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
199 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-370,1989 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,431,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,431,1995 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,431,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3271 No. of Facilities: 40 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 111 (estimated)

 Safety Information

Symbol GHS02 GHS08
GHS02, GHS08
Signal Word Warning
Hazard Statements H226-H351-H412
Precautionary Statements P273-P281
Hazard Codes Xn:Harmful
Risk Phrases R10;R40
Safety Phrases S36/37-S16
RIDADR UN 1993 3/PG 3
WGK Germany 3
RTECS DF6423800
Packaging Group III
Hazard Class 3
HS Code 29329900

 Synthetic Route

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

Coumarone
4-Chlorosulfonyl-2,1,3-benzothiadiazole
MFCD00005847
2,1,3-benzothiadiazole-4-sulfonylchloride
Benzo<a>pyrene
Benzo-2,1,3-thiadiazole-4-sulphonyl chloride
2,3-Benzofuran
EINECS 205-982-6
2,1,3-benzothiadiazol-4-sulfonyl chloride
1-Benzofuran
Benzofuran
benzofuran-
2,1,3-Benzothiadiazole,4-chlorosulfonyl
3,4-benzopyrene
2,3,4-TRIFLUOROBENZENEETHANOL
benzo[b]furan
2,1,3-benzothiadiazole-4-sulphonyl chloride
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