Selective nitroaldol condensations over heterogeneous catalysts in the presence of supercritical carbon dioxide

R Ballini, M Noè, A Perosa, M Selva

Index: Ballini, Roberto; Noe, Marco; Perosa, Alvise; Selva, Maurizio Journal of Organic Chemistry, 2008 , vol. 73, # 21 p. 8520 - 8528

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Citation Number: 14

Abstract

At 40− 60° C, in the presence of heterogeneous catalysts based on Al2O3, supercritical carbon dioxide not only acts as a good solvent for the reaction of aromatic and aliphatic aldehydes with 1-nitroalkanes but, most importantly, it also allows the selectivity to be tuned between the competitive formation of β-nitroalcohols and nitroalkenes (from the Henry reaction and the nitroaldol condensation, respectively). In particular, when the pressure ( ...