The Journal of organic chemistry

Synthesis of Trifluoromethyl Ketones via Tandem Claisen Condensation and Retro-Claisen C–C Bond-Cleavage Reaction

D Yang, Y Zhou, N Xue, J Qu

Index: Yang, Dongmei; Zhou, Yuhan; Xue, Na; Qu, Jingping Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4171 - 4176

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Citation Number: 16

Abstract

A highly efficient, operationally simple approach to trifluoromethyl ketones has been developed that builds on the use of a tandem process involving Claisen condensation and retro-Claisen C–C bond cleavage reaction. Enolizable alkyl phenyl ketones were found to react readily with ethyl trifuoroacetate under the promotion of NaH to afford trifluoroacetic ester/ketone exchange products, trifluoromethyl ketones, which were quite different from ...