2-Phenylacetophenone

Modify Date: 2026-07-02 16:43:02

2-Phenylacetophenone structure	Common Name	2-Phenylacetophenone
	CAS Number	451-40-1	Molecular Weight	196.245
	Density	1.1±0.1 g/cm3	Boiling Point	320.6±11.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₂O	Melting Point	54-55 °C(lit.)
	MSDS	Chinese USA	Flash Point	137.0±14.2 °C

Use of 2-Phenylacetophenone

2-Phenylacetophenone has broad-spectrum efflux pump inhibition activity. 2-Phenylacetophenone is a benzoin derivative used as a photoinitiator in vinyl polymerization[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	2-Phenylacetophenone
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	2-Phenylacetophenone has broad-spectrum efflux pump inhibition activity. 2-Phenylacetophenone is a benzoin derivative used as a photoinitiator in vinyl polymerization[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
In Vitro	2-Phenylacetophenone displays antibacterial activity against B. subtilis, M. smegmatis, and M. aurum with MICs of 500 µg/mL[1]. 2-Phenylacetophenone (1000 µg/mL) inhibits biofilm formation for M. smegmatis[1].
References	[1]. Hellewell L, et al. Chalcones, stilbenes and ketones have anti-infective properties via inhibition of bacterial drug-efflux and consequential synergism with antimicrobial agents. Access Microbiol. 2020 Feb 18;2(4):acmi000105.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.1±0.1 g/cm3
Boiling Point	320.6±11.0 °C at 760 mmHg
Melting Point	54-55 °C(lit.)
Molecular Formula	C₁₄H₁₂O
Molecular Weight	196.245
Flash Point	137.0±14.2 °C
Exact Mass	196.088821
PSA	17.07000
LogP	3.18
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.584
InChIKey	OTKCEEWUXHVZQI-UHFFFAOYSA-N
SMILES	O=C(Cc1ccccc1)c1ccccc1
Storage condition	2-8°C
Water Solubility	methanol: 0.1 g/mL, clear

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

2-Phenylacetophenone MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM9662500

CHEMICAL NAME :: Acetophenone, 2-phenyl-

CAS REGISTRY NUMBER :: 451-40-1

BEILSTEIN REFERENCE NO. :: 1072876

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H12-O

MOLECULAR WEIGHT :: 196.26

WISWESSER LINE NOTATION :: RV1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03836

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AM9662500
HS Code	29143900

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:134-81-6 Benzil CAS#:103-80-0 Phenylacetyl ch... CAS#:71-43-2 benzene CAS#:1689-71-0 Oxirane, 2,3-di...
CAS#:140-29-4 Benzyl cyanide CAS#:98-80-6 Phenylboronic acid CAS#:108-90-7 Chlorobenzene CAS#:98-86-2 Acetophenone
CAS#:32368-19-7 2-methylsulfany... CAS#:93-55-0 Phenyl ethyl ketone
DownStream 10
CAS#:3755-83-7 2-Methyl-4,5-di... CAS#:3469-00-9 methyl diphenyl... CAS#:81585-68-4 1,1,2-trimethox... CAS#:586-91-4 4,4'-azobisbenz...
CAS#:3524-62-7 Methyl benzoin CAS#:24242-77-1 2-iodo-1,2-diph... CAS#:613-42-3 4-BENZYLBIPHENYL CAS#:93-89-0 Ethyl benzoate
CAS#:350-92-5 1,1,1-Trifluoro... CAS#:495-18-1 Benzohydroxamic acid

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2914399090
Summary	2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Polycaprolactone/oligomer compound scaffolds for cardiac tissue engineering.

J. Biomed. Mater. Res. A 102(10) , 3713-25, (2014)

Polycaprolactone (PCL), a synthetic biocompatible and biodegradable polymer generally used as a scaffold material for tissue engineering applications. The high stiffness and hydrophobicity of the PCL ...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293

Total 196, Current Page 1 of 20

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Benzoin,deoxy

1,2-Diphenylethanone

MFCD00003081

benzyl phenyl ketone

1,2-diphenyl-ethanone

DESOXYBENZOIN

EINECS 207-193-2

Deoxybenzoin

Desoxybenzoine

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of 2-Phenylacetophenone?

A: SMILES notation of 2-Phenylacetophenone is O=C(Cc1ccccc1)c1ccccc1.

Q: What is the melting point of 2-Phenylacetophenone?

A: Melting point of 2-Phenylacetophenone is 54-55 °C(lit.).

Q: What is the LogP of 2-Phenylacetophenone?

A: LogP of 2-Phenylacetophenone is 3.18.

Q: What are the upstream materials of 2-Phenylacetophenone?

A: Related upstream materials(CAS) of 2-Phenylacetophenone: 134-81-6;103-80-0;71-43-2;1689-71-0;140-29-4;98-80-6;108-90-7;98-86-2;32368-19-7;93-55-0.

Q: What is the boiling point of 2-Phenylacetophenone?

A: Boiling point of 2-Phenylacetophenone is 320.6±11.0 °C at 760 mmHg.

Q: What is the polar surface area (PSA) of 2-Phenylacetophenone?

A: Polar surface area (PSA) of 2-Phenylacetophenone is 17.07000.

Q: What are the downstream products of 2-Phenylacetophenone?

A: Related downstream products(CAS) of 2-Phenylacetophenone: 3755-83-7;3469-00-9;81585-68-4;586-91-4;3524-62-7;24242-77-1;613-42-3;93-89-0;350-92-5;495-18-1.

Q: What English synonyms does 2-Phenylacetophenone have?

A: English synonyms of 2-Phenylacetophenone: Benzoin,deoxy, 1,2-Diphenylethanone, MFCD00003081, benzyl phenyl ketone, 1,2-diphenyl-ethanone, DESOXYBENZOIN, EINECS 207-193-2, Deoxybenzoin, Desoxybenzoine.

Q: What is the CAS number of 2-Phenylacetophenone?

A: CAS number of 2-Phenylacetophenone is 451-40-1.

Q: What are the uses of 2-Phenylacetophenone?

A: Main uses of 2-Phenylacetophenone: 2-Phenylacetophenone has broad-spectrum efflux pump inhibition activity. 2-Phenylacetophenone is a benzoin derivative used as a photoinitiator in vinyl polymerization[1].

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-Phenylacetophenone
Price: Check
Purity: 99.75%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Phenylacetophenone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2-Phenylacetophenone 451-40-1
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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