Copper??Catalyzed Regioselective Synthesis of N??Aryl Amides from Aldoximes and Aryl Halides

N Panda, R Mothkuri, DK Nayak

Index: Panda, Niranjan; Mothkuri, Raghavender; Nayak, Dinesh Kumar European Journal of Organic Chemistry, 2014 , vol. 2014, # 8 p. 1602 - 1605

Full Text: HTML

Citation Number: 7

Abstract

Abstract Ligand-assisted copper-catalyzed reaction of aldoximes with aryl halides is described for the regioselective synthesis of N-aryl amides. This protocol is simple and compatible with a wide range of functional groups attached to the aryl ring of the halides as well as aldoximes.

~78%

~64%

~30%

~66%

~51%

~82%

~60%

~90%

~77%

~59%

~72%

~62%

~49%

~63%

~75%

~55%

Copper catalyzed N-arylation between aryl halides and nitril...

[Wang, Jichao; Yin, Xinchi; Wu, Jun; Wu, Datong; Pan, Yuanjiang Tetrahedron, 2013 , vol. 69, # 48 p. 10463 - 10469]

A novel synthesis of N-arylamides from nitroarenes via reduc...

[Du, Xiaohua; Zheng, Mei; Chen, Sheng; Xu, Zhenyuan Synlett, 2006 , # 12 p. 1953 - 1955]