e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis and anticonvulsant activity of N-(benzoylalkyl) imidazoles and N-(. omega.-phenyl-. omega.-hydroxyalkyl) imidazoles

D Nardi, A Tajana, A Leonardi, R Pennini…

Index: Nardi; Tajana; Leonardi; Pennini; Portioli; Magistretti; Subissi Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 727 - 731

Full Text: HTML

Citation Number: 74

Abstract

Results Tables IV and V summarize the data on anticonvulsant activity obtained for the compounds prepared. N-Phenacylimidazole (42; log P= 1.03) and the corresponding alcohol, namely, N-(P-phenyl-6-hydroxyethy1) imidazole (47; log P= 0.99), showed no anticonvulsant activity. Also, when hydrophilic substituents (OH, OCH3, NH2, NHCOCH3, NHS02CH3, NO2) were introduced into the phenyl moiety (compounds 1-6, 43, 22-26; ...

2-(1H-imidazol-1-yl)-1-[4-(2-phenylethyl)phenyl]ethan-1-one Structure

2-(1H-imidazol-...

~79%

2-imidazol-1-yl-1-[4-(2-phenylethyl)phenyl]ethanol Structure

2-imidazol-1-yl...

Imidazole Structure

4'-(β-phenylethyl)-3-(dimethylamino)propiophenone hydrochloride Structure

4'-(β-phenyleth...

~57%

1-Propanone, 3-(1H-imidazol-1-yl)-1-(4-(2-phenylethyl)phenyl)- Structure

1-Propanone, 3-...

Imidazole Structure

~40%

2-imidazol-1-yl-1-(3-phenylphenyl)ethanone Structure

2-imidazol-1-yl...

2-(1H-imidazol-1-yl)-2-methyl-1-(4-phenethylphenyl)propan-1-one Structure

2-(1H-imidazol-...

~75%

2-(1H-imidazol-1-ium-1-yl)-2-methyl-1-[4-(2-phenylethyl)phenyl]propan-1-ol,chloride Structure

2-(1H-imidazol-...

Imidazole Structure

p-phenylphenacyl chloride Structure

p-phenylphenacy...

~67%

1,3-bis(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)-1H-imidazol-3-ium chloride Structure

1,3-bis(2-([1,1...

2-imidazol-1-yl-1-(4-phenylphenyl)ethanone Structure

2-imidazol-1-yl...

Imidazole Structure

~62%

2-(1H-imidazol-1-yl)-1-[4-(2-phenylethyl)phenyl]ethan-1-one Structure

2-(1H-imidazol-...

1-([1,1'-Biphenyl]-2-yl)ethanone Structure

1-([1,1'-Biphen...

~%

2-bromo-1-(2-phenylphenyl)ethanone Structure

2-bromo-1-(2-ph...

Methanesulfonyl chloride Structure

Methanesulfonyl...

1-(4-aminophenyl)-2-(1H-imidazol-1-yl)ethanone Structure

1-(4-aminopheny...

~35%

N-(4-(1H-Imidazol-1-ylacetyl)phenyl)methanesulfonamide Structure

N-(4-(1H-Imidaz...

2-imidazol-1-yl-1-(4-nitrophenyl)ethanone,hydrochloride Structure

2-imidazol-1-yl...

~%

N-(4-(1H-Imidazol-1-ylacetyl)phenyl)methanesulfonamide Structure

N-(4-(1H-Imidaz...

2-imidazol-1-yl-1-(4-nitrophenyl)ethanol,hydrochloride Structure

2-imidazol-1-yl...

~54%

N-(4-Amino-alpha-hydroxyphenethyl)imidazole hydrochloride Structure

N-(4-Amino-alph...

Formaldehyde Structure

Dimethylamine hydrochloride Structure

Dimethylamine h...

~%

dimethylaminomethanol Structure

dimethylaminome...

N-(4-(2-(1H-imidazol-1-yl)acetyl)phenyl)acetamide Structure

N-(4-(2-(1H-imi...

~62%

1-(4-aminophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone,methane,chloride Structure

1-(4-aminopheny...

Cyclohexylbenzene Structure

Cyclohexylbenzene

Chloroacetyl chloride Structure

Chloroacetyl ch...

~77%

2-Chloro-1-(4-cyclohexylphenyl)ethanone Structure

2-Chloro-1-(4-c...